I've had a hard time building the Quarantine given the lack of space in the arm, but I tried this and had fun. You need to skill for cooldown, as it benefits all weapon types with the quirks on this mech. First match put up 720 damage. I used SRM6 in the trial run but they were too spread out and cycled too slowly. SRM4 will be more accurate and benefit from the cooldown skills + quirks.
Tried this out last night. Swapped out ML for ERML, Laser AMS for AMS with half ton of ammo and dropped half ton of LB5X ammo. Basically reduces DPS marginally for some extra range.